anti-Caspase-11 (mouse), mAb (8A5) - 100 µg

Alternate_names :Caspase-11 (mouse) Description :Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditio ns. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymp hocyte apoptosis by activating both caspase-3 and caspase-7. Applications :ELISA | FACS | IP | WB Species_reactivity :Mouse, Rat Clone :8A5 Clonality :Monoclonal Concentration :1mg/ml Stability :Stable for at least 1 year after receipt when stored at -20C. Form :Liquid. In PBS containing 0.02% sodium azide.